An anime series produced by Production I.G and Aniplex and directed by Junichi Fujisaku. The series premiered in Japan on Sony's anime satellite channel, Animax, as well as on terrestrial networks such as MBS, TBS, and RKB on October 8, 2005. The final episode aired on September 23, 2006. Blood+ is licensed for international distribution in several regions through Sony Pictures' international arm, Sony Pictures Television International (SPTI). Blood+ was inspired by the 2000 anime film Blood: The Last Vampire; however, there are only a few allusions and basic elements from the film. Fujisaku has been involved with both works, including acting as the director for Blood+ and writing the novelization of Blood: The Last Vampire.
Under the care of her adoptive family, Saya Otonashi has been living the life of an anemic amnesiac, but otherwise ordinary schoolgirl. However, her happy life is shattered when she is attacked by a Chiropteran, learning that she is the only one who can defeat them. Armed with her special katana, Saya embarks on a journey with her family, allies, and her chevalier Haji, to rid the world of the Chiropteran threat and recover her identity. The course of the journey reveals the background history of the Chiropterans and Saya's past, which extends into the mid-19th century. The series is initially set in September 2005 Okinawa City (Koza), on Okinawa Island, near the US Kadena Air Base. Over the course of the series, Saya travels across the world, from Japan to Vietnam, Russia, France and finally the USA, fighting Chiropterans.
The Blood+ anime series premiered in Japan on October 8, 2005, on MBS/TBS, replacing Mobile Suit Gundam SEED Destiny, with a new episode airing weekly until the final episode aired September 23, 2006, totaling 50 episodes. The series is directed by Junichi Fujisaku and features original character designs by Chizu Hashii. Each season has separate opening and ending themes from a variety of artists, with the final episode using the season one ending theme. The series simultaneously aired on Animax, Sony's Japanese anime satellite channel, with its networks in Southeast Asia and South Asia also later airing the series. Through Sony's international division, Blood+ was licensed for distribution in multiple regions. The English dub of the series, aired in the United States on Cartoon Network's Adult Swim programming block, premiering March 11, 2007 and running till March 23, 2008. The English dub also aired in Australia on the Sci Fi Channel and in the Philippines on Studio 23. The first Region 1 DVDs were released in North America on March 4, 2008, with a simultaneous release of a single five-episode volume and a twenty-five episode box set, Blood+ Part One. Sony continued released individual volumes on a regular basis until the first half of the series was released. The second half was released in a second box set, Blood+ Part Two, on October 20, 2009. the entire series is available for free streaming in the US on Crackle, they are also available on Hulu and Netflix.